Protein Details: Potassium voltage-gated channel protein Shal

Protein ID

ICDB_Pro_0370

Protein Name

Potassium voltage-gated channel protein Shal

Gene Name

Shal; SHAL2; CG9262

Organism

Drosophila melanogaster (Fruit fly)

Length

571 amino acids

AlphaFoldDB

AF-P17971-F1-model_v4.pdb

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane; the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. May play a role in the nervous system and in the regulation of beating frequency in pacemaker cells

Sequence

MASVAAWLPFARAAAIGWVPIATHPLPPPPMPKDRRKTDDEKLLINVSGRRFETWRNTLEKYPDTLLGSNEREFFYDEDCKEYFFDRDPDIFRHILNYYRTGKLHYPKHECLTSYDEELAFFGIMPDVIGDCCYEDYRDRKRENAERLMDDKLSENGDQNLQQLTNMRQKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVVETVPCGHRPGRAGTLPCGERYKIVFFCLDTACVMIFTAEYLLRLFAAPDRCKFVRSVMSIIDVVAIMPYYIGLGITDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLVFSLAMAIIIFATVMFYAEKNVNGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRKAQRKARLARIRIAKASSGAAFVSKKKAAEARWAAQESGIELDDNYRDEDIFELQHHHLLRCLEKTTDREFVELEIPFNGQPKRPGSPSPMASPAHSTNSAAGLLQSCCGRCCSQRYQACGKYMPAASNAQNSQNNQPMDGTYLVEASF

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Co-expressed with SIDL in the nervous system.

DOI ID

10.1126/science.2333511; 10.1093/nar/18.8.2173; 10.1126/science.287.5461.2185; 10.1186/gb-2002-3-12-research0083; 10.1016/j.mcn.2010.06.001

RefSeq

NP_001097646.1 [P17971-2]; NP_524159.1 [P17971-1]